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Front Immunol ; 11: 2086, 2020.
Article in English | MEDLINE | ID: covidwho-771524

ABSTRACT

Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).


Subject(s)
Betacoronavirus/genetics , Churg-Strauss Syndrome/complications , Churg-Strauss Syndrome/drug therapy , Coronavirus Infections/complications , Cyclophosphamide/therapeutic use , Granulomatosis with Polyangiitis/complications , Granulomatosis with Polyangiitis/drug therapy , Immunosuppressive Agents/therapeutic use , Pneumonia, Viral/complications , Adult , Antiviral Agents/therapeutic use , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/virology , Drug Therapy, Combination , Glucocorticoids/therapeutic use , Humans , Immunocompromised Host , Male , Pandemics , Pneumonia, Viral/drug therapy , Pneumonia, Viral/virology , Prednisolone/therapeutic use , RNA, Viral/genetics , Reverse Transcriptase Polymerase Chain Reaction , Rituximab/therapeutic use , SARS-CoV-2 , Treatment Outcome
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